Mining the Potential of Srotas Bioinformatics Tools for Therapeutic Innovation

Abstract

Background: Traditional systems like Ayurveda describe bodily channels (Srotas) as pivotal to maintaining physiological and pathological balance. The intersection of Srotas theory with modern bioinformatics offers an untapped domain for therapeutic exploration.

Objective: This study aims to systematically review the landscape of bioinformatics tools inspired by or applicable to the Ayurvedic Srotas system and evaluate their potential in driving innovative therapeutic strategies. Methods: A systematic review was conducted following PRISMA guidelines using databases like PubMed, Scopus, AYUSH Research Portal, and Google Scholar. Keywords included "Srotas", "Ayurveda bioinformatics", "therapeutic innovation", and "Ayurgenomics". Eligible articles (2010–2024) were screened and analyzed. Selected studies were appraised using narrative synthesis and thematic categorization.

Results: Of 210 records identified, 36 studies met inclusion criteria. Emerging Srotas-based models in Ayurgenomics, network pharmacology, and systems biology were highlighted. These studies demonstrate potential in drug repurposing, formulation optimization, and predictive pathology mapping.

Conclusion: Integration of Srotas theory with bioinformatics tools opens novel paradigms for therapeutic innovation by aligning traditional knowledge with precision medicine. However, interdisciplinary collaboration and computational tool development tailored to Ayurvedic physiology are essential.