Pharmacoeconomic Analysis of Cervical Cancer Cases Specific to Serotypes 16 and 18 Based on the Analysis of Protective Determinants and Risk Factors Based on Activity-Based Accounting in Morocco

Abstract

With 2057 new cases of cervical cancer and 923 deaths each year in Rabat, and most of the cases (80%) occur at the age of 45, Morocco is facing a public health problem that absorbs huge expenses from the health system and that requires reflection to minimize costs and reduce premature deaths of married women of childbearing age. Method: Faced with this emerging problem, a cohort study was carried out on 250 women over 5 years in the Rabat region to study the risk and protective factors against cervical cancer. Results: The study found two protective factors: diet rich in vitamin A and C (RR: 2.9 [1.69 to 4.18]) and use of progestin-only injectable contraceptives (RR :0.5[0.36 to0.75]), as well as risk factors, mainly smoking (RR :9.8[9.51 to 9. 93]), Menopause (RR :1.3[1.21 to 1.76]), Post coital metrorrhagia (RR :4.83[1.63 to 5.01]), Previous history of clamidiya (RR :3.9[1.67 to 6. 01]), Hemoglobin level≤10g/dl (RR :6.8[4.13 to6.01], use of oestro-progestins≥10 years (RR :5.9[4.36 to 7.01], multiple partners (5.6[1.56 to6.75]. In addition, the study used the analysis of their cost per activity approach to allow a better diagnosis of the causes of direct and indirect costs as well as the search to reduce the burden on the health system and to reduce premature mortality in the working population. Conclusion: The cost to meet the expenses of cervical cancer is estimated at 12 783 138 907 160 Є, while the cost of vaccination that will cover the entire female Moroccan population aged 10 to 14 years is 1526000 is estimated 67 296 600 Є, and the cost of vaccine is estimated 44.9 Є which will save the health system a cost minimization that is around 12 783 071 610 560 Є. Conclusion: the cost to meet the expenses of cervical cancer is estimated at 12,783,138,907,160 Є, while the cost of vaccination that will cover the entire female Moroccan population aged 10 to 14 years is 1526,000 is estimated 67,296,600 Є, and the cost of vaccine is estimated 44.9 Є which will save the health system a cost minimization which is around 12,783,071,610,560 Є.