Docetaxel Surface Engineered Polymeric Nanoparticles for Improved Cancer Chemotherapy: Fabrication and Characterization

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Sapana Shyamal Chaudhari , Chainesh Shah Shahzad Ahmed A. R

Abstract

It is commonly known that docetaxel (DTX) is an effective treatment for cancer. It has to do with a solubility issue that can be fixed by adding polysorbate 80, and it is marketed commercially. To improve DRX's anticancer effectiveness and lessen adverse effects, alternative delivery methods or techniques must be used, as DTX with polysorbate 80 has substantial side effects, adverse reactions and extended pharmacological actions. Creating and producing docetaxel-loaded surface folate-decorated and pegylated PLGA (PPegF) nanoparticles and assessing them in vitro drug release, drug loading, polydispersity index, zeta potential, and particle size were the main objectives of this study. Using polyvinyl alcohol as a surfactant, the nanoparticles were created using the modified nanoprecipitation technique. The optimal formulation, PVAF4, was chosen based on the results of the in vitro drug release characteristics inquiry so that its surface shape could be examined using SEM and TEM. The PVAF4 formulation was also subjected to the MTT assay. According to an in vitro release kinetics investigation, the delivery mechanism followed the Korsmeyer-Peppas model, which postulated "Fiskian diffusion." Additionally, the PVAF4 nanoformulations outperformed the free medication in the MTT assay. The study used PVA as the only surfactant to clearly construct and characterise the folate coated pegylated PLGA nanoparticle.

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