Assessment of Antioxidant Activities of Albizzia Lebbeck Loaded Solid-Lipid Nanoparticles

Abstract

Background: Nanotechnology is vital role in therapeutic industry, SLNs combine lipid-based systems with nanotechnology to provide controlled drug release, & antioxidants in SLNs improves their efficacy in treating diseases to oxidative stress. Aim: To study the detail about Assessment of antioxidant activity of Albizzia Lebbeck loaded solid-lipid nanoparticles. Material & methods: However, very few studies have incorporated with antioxidant plant Al leaves extract into the SLNs. In the current study, ethanolic extract from the leaves of Al has been SLNs using stearic acid. The substance was further characterized by morphological, and chemical analysis using FE-SEM, FTIR, and BET techniques. The antioxidant properties of the drug were evaluated using various scavenging assays, including DPPH, superoxide, hydroxyl, nitric oxide, and the exhibited scavenging activity with an IC₅₀ value of 34.69 µg/ml, 20.88 µg/ml, 60.00 µg/ml, 43.11 µg/ml, and 96.06 µg/ml, respectively, compared with ascorbic acid. In comparison to ascorbic acid, Results & Discussion: SLNs shows less effectiveness against certain radicals but exhibits stronger activity against superoxide. This SLNs could be effective in treating conditions primarily affected by these specific radicals. The MTT assay on C6 cells found that concentrations from 12.5 to 200 mg/L initiated apoptosis through cell collapse, reduced production of apoptotic.  In summary, it is show that significant potential for pharmaceutical formulations & antioxidant stree release is required, it managing neurological diseases.