Phytochemical Investigation and Pharmacological Evaluation of Indian Medicinal Plant Extract, and Characterization of Bioactive Phytoconstituents for Anti-inflammatory Activity

Abstract

Vascularized living tissue responds to a local insult by becoming inflamed. We began looking for novel anti-inflammatory medications from indigenous sources due to the terrible adverse effects of both steroidal and non-steroidal anti-inflammatory treatments. The anti-inflammatory properties of the methanol extract of Clerodendron infortunatum Linn. (MECI) leaves were assessed in relation to rat paw edoema caused by dextran, histamine, and carrageenan. The methanol extract, at doses of 250 and 500 mg/kg body weight, had noteworthy efficacy (p<0.01) against every pharmacological agent examined. Phynylbutazone was used as a reference medication to compare all of these effects.