Evaluation of Antiobesity Activity Potential of Bioactive Constituents in Some Natural Plants

Abstract

The aim of the present investigation involves the ethanolic extract of Alpinia calcarata rhizomes were subjected to phytochemical screening. The result indicated that, rhizome extract shows the presence of carbohydrate, proteins, cardiac glycosides, flavonoid, tannins and phenol. Phytochemicals are natural bioactive compounds found in plants. They are mainly two groups, which are primary and secondary metabolites. Primary metabolites are sugars, amino acids, proteins and chlorophyll while secondary metabolites consist of alkaloids, terpenoids and phenolic compounds. The activity of the ethanolic extract of Alpinia calcarata was orally bioscreened in progesterone-induced obese mice at 200 mg/kg/bw and 400 mg/kg/bw. Body mass index was calculated once per week for four weeks and blood samples were obtained at the end of the experiment for lipid profile analysis. Antiobesity activities of the rhizome extracts were compared with the controls. ethanolic extract of Alpinia calcarata rhizomes, at dose concentrations of 200 mg/kgbw and 400 mg/kgbw, showed significant effects on body mass index when compared to standard Semaglutide.