Potential Herbal Anti-Cancer Drug Formulations Using Modern Drug Delivery Methods

Abstract

Objectives: The goal of the current effort is to create and assess chewing gum containing a potassium salt of curcumin extract for its ability to carry medication into the buccal cavity and fight cancer. It helps with the treatment of metabolic syndrome, arthritis, anxiety, and hyperlipidemia as well as oxidative and inflammatory diseases. Chewing gums containing curcumin were created to examine its anticancer properties.

Method: To increase the solubility of potassium Curcuminate, a solid dispersion of the compound was created utilising -cyclodextrin. For the purpose of improving solubility, the obtained solid dispersion of potassium curcuminate was examined. Curcuminate Sucrose, castor oil, chewing gum base, potassium curcuminate, and other ingredients were then combined to create chewing gums. The prepared chewing gum was assessed for colour, flavour, hardness, and drug-excipient compatibility.

Results: The compatibility study's findings demonstrated that there was no interaction between the chosen medicine and excipients. When compared to curcumin and other common anticancer medications like 5-Fu, Mito-C, and Paclitaxel, potassium curcuminate has greater anticancer activity: 85% against prostate cancer cells, 80% against liver cancer cells, and 92% on average against colon cancer cells. In-vivo studies of the chewing gums were optimised based on in-vitro drug release.

Conclusion: According to the results of this study, chewing gum containing the potassium salt of the cancer-fighting compound curcumin can be deemed a good delivery mechanism.