Micellization of Ammonium Dodecyl Sulfate in Binary System in Presence of Azithromycin and Piroxicam

Abstract

The micellization properties of anionic surfactant Ammonium dodecyl sulfate (ADS) has been investigated in presence of three binary micellar mediums for two drugs. The micellar systems were ADS+ Pluronic L-35, ADS+Pluronic L-64 and ADS+Pluronic P-123. The two drugs used were Azithromycin (AZI) and Piroxicam (PYM). The investigations were carried out through UV- visible spectroscopy, FTIR Spectroscopy and Conductivity studies. There was greater binding of both the drugs in presence of ADS+P-123 as observed from UV spectroscopic measurements. This was because of probable high molecular weight and lower HLB compared to the other two binary pluronic combinations. The Gibbs free energy of micellization,  was negative for all the six combinations of binary system and drugs predicting that the reactions are spontaneous in nature. The lowering of CMC of ADS in a gradually manner while proceeding from ADS, ADS+P-123, ADS+P-123+drug presumes that there is greater solubilization of drug in the mixed micellar system.