Evaluation Of The Effectiveness Of Use Of A Complex Preparation Containing Glycine, Zinc And Curcumin As A Stress Protective Agent

Abstract

We have developed a substance for pharmacocorrection of stress, conventionally called Kurglycin, with the ratio of components, %: zinc - 12.04, curcumin - 67.68, glycine - 13.65, water - 6.63. 14-day and 21-day oral administration of Kurglycin in the form of a 3% suspension at a dose of 5 ml/kg orally had a positive effect on the course of the stress reaction in the adrenal cortex, stabilizing the secretory activity of glucocorticoid-producing cells and reducing cortisol levels to levels close to control, in both studied groups of animals. The study of changes in the biochemical parameters of rats with low level of emotion (LLE) and high level of emotion (HLE) under the influence of Kurglycine showed a certain difference in the susceptibility of these groups both to the action of the drug.