Hepatoprotective Activity of Aqueous Leaf Extract of Pako (Diplazium esculentum) Plant against Chloroform Induced Albino Rats

Abstract

Background

In this study, we wanted to determine the hepato-protective property of pako leaves extract (Diplazium esculentum) in Swiss albino rats and compare the effect of different rates of fiddle fern (Diplazium esculentum).

Methods

The in-vivo hepatoprotective effect of the aqueous extract of Diplazium esculentum (Retz.) Sw. against chloroform induced hepatotoxicity in albino rats was studied. The test rats were brought from PITAHC-DOH animal facility, the plant extraction was carried out at ROCO buildin, Cagayan State University (CSU) Carig Campus, College of Arts and Science, Carig Sur, Tuguegarao city, and the test was conducted at the PITAHC-DOH animal facility, after obtaining clearance from Institutional Ethics Committee.

Results

In the mean total protein, there was no significant mean difference between the treatments with the increase in dose rate of Fiddle fern extract given to the animals (P = 0.338), Significant differences were observed for the SGPT between the control group (T2) and the group treated with 20 g/kg extract (P = 0.024). There were no significant differences detected for the (T1) negative control group with T4-extract with 40 g/kg and T2-treated with essential.

Conclusion

The 40 g/kg of the fiddlehead fern extract prevents liver damage comparably similar to those with essential and the normal control group. To conclude, the death was prevented with administration of the extract 20 and 40 g/kg.