Formulation, Development and Preformulation Studies of Eukalyptol & Thymol Containing organogels for Topical Delivery System

Abstract

There are many benefits to using a topical application as opposed to the more traditional methods of administering drugs systemically. The stratum corneum serves as an important defence mechanism against the introduction of potentially harmful foreign molecules; however, this barrier prevents most medications from penetrating the skin via the skin's surface. Penetration enhancers, which come in a variety of forms, have been shown to successfully circumvent this barrier and facilitate the efficient transport of medicines through the skin. Some skin penetration enhancers are connected with unpleasant and harmful consequences, despite the fact that the pharmaceutical industry already uses them in commercially available transdermal medications. This highlights the importance of finding novel skin penetration enhancers that are both safe and effective. Natural penetration enhancers are more widely utilised than their synthetic equivalents because they may be produced in large quantities using a renewable resource, and they can be cheaper to extract depending on the method used. The purpose of this article is to provide a synopsis of the findings from scientific studies of natural skin penetration enhancers.